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The best way to make a Meatloaf Sandwich is to keep it simple. Here’s what you need: a couple of lightly toasted bread slices (wheat, white or sourdough), slices of ripe red tomato and sweet red onion, good quality mayonnaise (ketchup or BBQ sauce optional), and a slab of delicious leftover meatloaf.

Meatloaf Sandwich served on a plate with potato chips and a beer in the background.

I’ve shared my two favorite meatloaf recipes (Turkey Meatloaf and Meatloaf with Oatmeal), they’re one of my go-to comfort foods. And while they’re wonderful the day they’re made, sandwiches made with the leftovers are even better, particularly with a pile of potato chips and an ice cold beer.

Ingredients You Need to Make a Meatloaf Sandwich

  • Sandwich Bread: whole wheat, white or sourdough – nothing too dense or thick
  • Cold, Leftover Meatloaf: I recommend either my mushroom loaded Turkey Meatloaf or my Meatloaf with Oatmeal
  • Mayonnaise: best quality mayonnaise, ideally homemade mayonnaise
  • Ketchup or BBQ Sauce: optional
  • Onion: sweet onion or red onion

Recipe Tips

  • Leftover meatloaf is easy to slice when it’s very cold, so cut it with a sharp or serrated knife straight from the refrigerator.
  • Cut yourself a thick, meaty slice so the meatloaf flavor is the star of the sandwich.
  • Don’t be stingy with the mayonnaise. And feel free to add ketchup, but only if you’re someone who loves it – it’s not essential to the balance of flavors in the sandwich.
  • Go for a slice of sweet onion or a red onion rather than a standard yellow onion that might overpower the other flavors.

Meatloaf Sandwich

5 from 1 vote
Prep: 10 minutes
Total: 10 minutes
Course: Main Course
Cuisine: American
Calories: 682
Servings: 4 people
This sandwich is all about simplicity – just enough ingredients to enhance the already delicious flavor of leftover meatloaf.


  • 8 slices sourdough sandwich bread or other sandwich bread
  • 6 tablespoons mayonnaise
  • ketchup or BBQ sauce to taste, optional
  • 4 thick slices leftover meatloaf ideally leftover Meatloaf with Oatmeal or Turkey Meatloaf
  • 2 medium tomatoes sliced
  • 1 medium red onion sliced


  • Lightly toast bread slices. Spread desired amount of mayonnaise and ketchup or BBQ sauce (if using) on two slices of bread. On one slice layer on meatloaf followed by desired amount of tomato and onion. Top with remaining bread slice and cut in half if desired. Repeat with remaining ingredients and serve.


Calories: 682kcal | Carbohydrates: 79g | Protein: 36g | Fat: 19g | Saturated Fat: 5g | Polyunsaturated Fat: 11g | Monounsaturated Fat: 4g | Trans Fat: 1g | Cholesterol: 103mg | Sodium: 1325mg | Potassium: 804mg | Fiber: 5g | Sugar: 11g | Vitamin A: 782IU | Vitamin C: 14mg | Calcium: 112mg | Iron: 8mg

Nutrition information is automatically calculated, so should only be used as an approximation.

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  1. David @ Spiced says:

    5 stars
    This is the ultimate in comfort food! In fact, this is a case where the leftovers might actually be better than the original. I do love a good meatloaf sandwich, and I can’t wait to try your version!!

  2. angiesrecipes says:

    I love the idea of using leftover meatloaf for the sandwiches and This would be GREAT for a workday lunch! I am going to make an extra large meatloaf next time, just for this sandwich.